RNA homeostasis deregulation is at the heart of several human diseases- from cancer to brain disorders and inflammation. Degradation and transcription both regulate RNA levels in the cell but do they act as isolated processes? or is there a cross-talk that connects the two?
What processes govern the balance of synthesis and degradation to maintain a steady state level of RNA?
How do disease states like cancer proliferate better despite the deregulation of RNA homeostasis?
How do mutations in a general RNA degradation machinery cause disorders like pontocerebellar hypoplasia?
My lab will aim to identify the mechanisms that are critical to cell survival during stress in transcriptionally deregulated diseases including cancer.
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This is the era of RNA biology. In a world that needs solutions to challenging health conditions, furthering RNA research will lead to novel discoveries and innovative solutions to manage diseases like cancer, brain disorders, and inflammation.
Contact
Jitendra K Meena, Ph.D.
RNA biologist
Therapeutic Innovation Center, Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Jitendra K Meena, Ph.D.
Instructor
Susan G. Komen Postdoctoral Fellow
Advisor- Dr. Thomas Westbrook, Ph.D., Co-founder of THINC
Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, TX 77030
[email protected], 8329085537
